C-Reactive Protein Levels are Elevated in Patients with Periodontitis and Their CRP Levels May Go Down After Periodontal Therapy

Article Title and Bibliographic Information

A systematic review and meta-analyses on C-reactive protein in relation to periodontitis.

Paraskevas S, Huizinga JD, Loos BG.

J Clin Periodontol 2008;35(4):277-90.

Level of Evidence

Level 1: Good-quality, patient-oriented evidence.

Strength of Recommendation Grade

Grade A: Consistent, good-quality patient-oriented evidence.

Purpose/Question

Are CRP levels significantly increased in periodontitis patients and what is the effect of periodontal therapy on their CRP levels?.

Source of Funding

Industry – Unrestricted grant from Philips Oral Healthcare EMEA.

Type of Study/Design

Systematic review and meta-analysis of observational and experimental studies.