Journal of Evidence-Based Dental Practice
Volume 8, Issue 4 , Pages 240-241, December 2008

Psychological Characteristics Such as Depression, Independent from a Known Genetic Risk Factor, Increase the Risk of Developing Temporomandibular Disorder Pain

Assistant Professor, Dental Public Health Sciences, University of Washington, Seattle, WA

Article Title and Bibliographic Information

Influence of psychological factors on risk of temporomandibular disorders.

Slade GD, Diatchenko L, Bhalang K, Sigurdsson A, Fillingim RB, Belfer I, et al.

J Dent Res 2007;86(11):1120-5.

Level of Evidence

Level 1 (Good quality, patient-oriented evidence)

Strength of Recommendation Grade

Grade B (Inconsistent or limited-quality patient-oriented evidence)

Purpose/Question

The authors aimed to answer 4 questions:

1.Is sensitivity to standardized noxious stimuli (perceived usually as painful) predictive of TMD risk?

2.What psychological characteristics are associated with pain sensitivity?

3.Are those same psychological characteristics predictive of TMD risk?

4.Is the magnitude of TMD risk associated with those psychological factors attenuated after adjustment for variants of the gene encoding COMT?

Source of Funding

Multiple grants from the National Institutes of Health, US Government.

Type of Study/Design

Small Cohort Study

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PII: S1532-3382(08)00187-5

doi:10.1016/j.jebdp.2008.09.019

Journal of Evidence-Based Dental Practice
Volume 8, Issue 4 , Pages 240-241, December 2008