Intravenous Bisphosphonate Therapy may Lead to Osteonecrosis of the Jaw in Multiple Myeloma, Breast, and Prostate Cancer Patients

Article Title and Bibliographic Information

Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy

Wang EP, Kaban LB, Strewler GJ, Raje N, Troulis MJ.

J Oral Maxillofac Surg 2007;65:1328-31

Strength of Recommendation

C

Purpose/Question

To determine the incidence of ONJ in a cohort of patients with multiple myeloma (MM), breast cancer (BC), or prostate cancer (PC) who were receiving intravenous bisphosphonate therapy for an established period of time.

Source of Funding

American Association of Oral and Maxillofacial Surgeons Student Training Award; Office of Enrichment Programs, Harvard Medical School; and the Department of Oral and Maxillofacial Education and Research Fund.

Type of Study/Design

Retrospective chart review