Intensive Periodontal Treatment Including Extractions is Associated with More Immediate Systemic Inflammation But Improved Longer-Term Endothelial Function Compared to Simple Scaling

Article Title and Bibliographic Information

Treatment of Periodontitis and Endothelial Function

Tonetti MS, D'Aiuto F, et al.

N Engl J Med 2007;356(9):911-20

Level of Evidence

1b

Purpose/Question

How is endothelial function, a marker of peripheral cardiovascular health, together with circulating levels of systemic markers of inflammation, altered following either intensive treatment of periodontitis (including extractions), or simple periodontal treatment?

Source of Funding

Government

Type of Study/Design

Randomized Controlled Trial