Journal of Evidence-Based Dental Practice
Volume 7, Issue 4 , Pages 167-169 , December 2007

Premedication with Low-dose Dextromethorphan Does Not Reduce Pain Following Oral Surgery

References 

  1. Minn FL, Nelson SL, Brahim J, Caruso FS. Superior analgesic activity of morphine with dextromethorphan, an NMDA receptor antagonist in oral surgery pain. Clin Pharmacol Ther. 1998;63:140
  2. Caruso FS, Mehlisch DR, Minn FL, Daniels SE, Nemarich AN, Conforto ME. Synergistic analgesic interaction of morphine with dextromethorphan, an NMDA receptor antagonist in oral surgery pain. Clin Pharmacol Ther. 1998;63:139
  3. Gordon SM, Dionne RA, Dubner R. Antihyperalgesic effect of the the N-methyl-D-aspartate receptor antagonist dextromethorphan in the oral surgery model. J Clin Pharmacol. 1999;39:139–146
  4. Cooper SA, Beaver WT. A model to evaluate mild analgesics in oral surgery outpatients. Clin Pharmacol Ther. 1976;20:241–250
  5. Max MB, Laska EM. Single-dose analgesic comparisons. In:  Max M,  Portenoy R,  Laska E editor. Advances in pain research and therapy. New York: Raven Press, Ltd; 1991;p. 55–95
  6. Gordon SM, Hamza M, Chuang B, Wang XM, Dionne RA. Differential effects of bupivacaine and lidocaine on PGE2 release, cyclooxygenase gene expression, and pain in a clinical pain model. In press, Anesth Analg.
  7. Gordon SM, Brahim JS, Dubner R, McCullagh LM, Sang CN, Dionne RA. Attenuation of pain in a randomized trial by suppression of peripheral nociceptive activity in the immediate postoperative period. Anesth Analg. 2002;95:175–183
  8. Henderson DJ, Withington BS, Wilson JA, Morrison LMM. Perioperative dextromethorphan reduces postoperative pain after hysterectomy. Anesth Analg. 1999;89:399–402
  9. Chia YY, Liu K, Chow LH, Lee TY. The operative administration of intravenous dextromethorphan reduces postoperative morphine consumption. Anesth Analg. 1999;89:748–752
  10. Weinbroum AA, Rudick V, Paret G, Ben-Abraham R. The role of dextromethorphan in pain control. Can J Anaesth. 2000;47:585–596
  11. Kawamata T, Omote K, Kawamata M, Namiki A. Premedication with oral dextromethorphan reduces postoperative pain after tonsillectomy. Anesth Analg. 1998;86:594–597
  12. Grace RF, Power I, Umedaly H, et al. Preoperative dextromethorphan reduces intraoperative but not postoperative morphine requirements after laparotomy. Anesth Analg. 1998;87:1135–1138
  13. Wu CT, Yu YC, Yeh CC, et al. Preincisional dextromethorphan treatment decreases postoperative pain and opioid requirement after laparoscopic cholecystectomy. Anesth Analg. 1999;88:1331–1334
  14. Wong CS, Wu CT, Yu JC, Yeh CC, Lee MMS, Tao PL. Preincisional dextromethorphan decreases postoperative pain and opioid requirement after modified radical mastectomy. Can J Anaesth. 1999;46:1122–1126
  15. Yeh CC, Ho ST, Kong SS, Wu CT, Wong CS. Absence of the preemptive analgesic effect of dextromethorphan in total knee replacement under epidural anesthesia. Acta Anaesthesiol Sin. 2000;38:187–193

PII: S1532-3382(07)00137-6

doi: 10.1016/j.jebdp.2007.09.002

Journal of Evidence-Based Dental Practice
Volume 7, Issue 4 , Pages 167-169 , December 2007

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