Journal of Evidence-Based Dental Practice
Volume 7, Issue 1 , Pages 19-20, March 2007

Synthetic Platelet-Derived Growth Factor (rhPDGF) May Improve Bone Fill Over β-Tricalcium Phosphate (β-TCP) Alone

Dalhousie University, Faculty of Dentistry, Division of Periodontics, Halifax, NS B3H3J5 Canada

Article Title and Bibliographic Information

Platelet-Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain: Results of a Large Multicenter Randomized Controlled Trial

Nevins M, Giannobile WV, McGuire MK, Kao RT, Mellonig JT, Hinrichs JE, et al.

J Periodontol 2005;76(12):2205-15

Level of Evidence

1a

Purpose/Question

1. Among adults with chronic periodontitis and infrabony pockets, is synthetic platelet-derived growth factor (rhPDGF–BB) plus bone substitute (β-tricalcium phosphate [β-TCP]) more effective in regeneration than bone substitute alone?

2. Among adults with chronic periodontitis and infrabony pockets, is 0.33 mg/mL rhPDGF–BB plus β-TCP more effective in regeneration than 1.0 mg/mL rhPDGF–BB plus β-TCP?

Source of Funding

Industry: BioMimetic Therapeutics, Franklin, Tennessee

Type of Study/Design

Multicenter Triple-Blinded Randomized Controlled Trial

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PII: S1532-3382(06)00206-5

doi:10.1016/j.jebdp.2006.12.012

Journal of Evidence-Based Dental Practice
Volume 7, Issue 1 , Pages 19-20, March 2007

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