Synthetic Platelet-Derived Growth Factor (rhPDGF) May Improve Bone Fill Over β-Tricalcium Phosphate (β-TCP) Alone

Article Title and Bibliographic Information

Platelet-Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain: Results of a Large Multicenter Randomized Controlled Trial

Nevins M, Giannobile WV, McGuire MK, Kao RT, Mellonig JT, Hinrichs JE, et al.

J Periodontol 2005;76(12):2205-15

Level of Evidence

1a

Purpose/Question

1. Among adults with chronic periodontitis and infrabony pockets, is synthetic platelet-derived growth factor (rhPDGF–BB) plus bone substitute (β-tricalcium phosphate [β-TCP]) more effective in regeneration than bone substitute alone?

2. Among adults with chronic periodontitis and infrabony pockets, is 0.33 mg/mL rhPDGF–BB plus β-TCP more effective in regeneration than 1.0 mg/mL rhPDGF–BB plus β-TCP?

Source of Funding

Industry: BioMimetic Therapeutics, Franklin, Tennessee

Type of Study/Design

Multicenter Triple-Blinded Randomized Controlled Trial