DNA sequence variations in the genes MSX1 and TGFA may lead to developmentally missing teeth
Original Article
Vieira AR, Meira R, Modesto A, Murray JC. MSX1, PAX9, and TGFA contribute to tooth agenesis in humans. J Dent Res 2004;83(9):723-7.
Level of Evidence
3b
Purpose
The purpose of this study was to determine the association between developmentally missing teeth (hypodontia) and sequence variations in the genes MSX1, PAX9, and TGFA in an ethnically diverse population.
Source of Funding
National Institutes of Health
Type of Study/Design
A case/parent trio study
Associate Professor, Pediatric Dentistry, School of Dentistry, University of Washington, Seattle, Washington
ABSTRACT